Cellular Proteases as Cancer Biomarkers: A Review

  • Sarah R. Röthlisberger INSTITUTO TECNOLÓGICO METROPOLITANO, Medellín
  • Fabián M. Cortes INSTITUTO TECNOLÓGICO METROPOLITANO, Medellín
Keywords: Cancer biomarkers, gene, kallikreins, metalloproteinases, protein.

Abstract

Over the past few decades a variety of biomolecules have been proposed as diagnostic biomarkers and predictors of severity for transmissible and nontransmissible diseases. Studies in a range of cancers have revealed many biomarkers with great potential in cancer diagnosis, in establishing tumor stage, progression, and response to therapies; such as the Kallikrein and Metalloproteinase families. Traditionally blood (serum) and tissue have been the main biological sources of biomarker discovery, but in the past decade urine has emerged as a promising source of cancer biomarkers. In this review we will focus on two large families, the Kallikrein family of serine proteases discovered in serum, and the Metalloproteinase family of zinc proteases discovered in urine, as potential cancer biomarkers.

Author Biographies

Sarah R. Röthlisberger, INSTITUTO TECNOLÓGICO METROPOLITANO, Medellín
Centro de Investigación, INSTITUTO TECNOLÓGICO METROPOLITANO, Medellín
Fabián M. Cortes, INSTITUTO TECNOLÓGICO METROPOLITANO, Medellín

Facultad de Ingeniería, Programa de Ingeniería Biomédica, INSTITUTO
TECNOLÓGICO METROPOLITANO, Medellín

How to Cite
Röthlisberger, S. R., & Cortes, F. M. (2010). Cellular Proteases as Cancer Biomarkers: A Review. TecnoLógicas, 97-114. https://doi.org/10.22430/22565337.467

Downloads

Download data is not yet available.
Published
2010-12-15
Section
Articles